Simcha’s research focuses on the intersection of policy, R&D, and healthcare practice. His projects examine challenges involved in building successful science-based ventures, in implementing disruptive technological innovations in healthcare settings, and in organising scientific work in an academic landscape that is increasingly internationally interconnected and tied into industrial R&D. In this research, Simcha builds on theory in the sociology, technology management, and entrepreneurship literature.
R&D dynamics in sectors such as the life sciences sector, where innovation is often science-driven, constitute a first focus in Simcha’s research. He has developed templates for business models of science-based ventures and advanced our understanding of trade-offs managers of such ventures face in the organisation of R&D. Simcha published several ESRC-funded studies on R&D strategies of US and UK biotechnology firms, and interactions of these firms with academic laboratories. In addition, he developed a valuation tool for science-based R&D projects in the context of a TSB-funded project on the cell therapy sector. Currently, Simcha builds on his work in this area to examine policy interventions in healthcare fields such as maternal and neonatal health where corporate R&D activity is comparatively weak.
Personalised medicine is another focus in Simcha’s work and he leads a number of interdisciplinary projects that examine the challenges policy makers, firms, and healthcare delivery organisations face in this field. Simcha collaborates in these projects with clinical researchers and practitioners from UCL’s hospital networks, as well as industrial partners. With support from Janssen Pharmaceuticals and TSB, he has done research on organisational and commercial challenges involved in the incorporation of advanced ‘point of care’ diagnostics services in infectious disease management in the NHS. With support from Siemens, Simcha is working with a team at the UCL Royal Free Hospital to assess the economic and clinical value of various new patient stratification strategies that involve primary care trusts in the management of liver disease. With support from NIHR, Simcha is involved in research at UCLH that examines the use of advanced imaging data in stratifying patients in oncology care. Finally, Simcha is studying the implementation of novel integrated decision support systems that seek to bring complex advanced molecular diagnostics information such as next generation genomic sequencing information, to routine clinical care at a number of major academic hospitals in the US.
The changing organisational dynamics in science as academic work has become more international, and closely interlinked with industrial R&D constitute a third focus in Simcha’s research. He published articles that examine institutional models governing academic work in the life sciences at Silicon Valley universities Berkeley, Stanford, and UCSF that are central nodes in biomedical innovation networks. Currently, Simcha is working on projects that examine the organisation and politics of international scientific consortia in the biomedical and geosciences fields, as well as changes in European systems of higher learning.
Simcha does not only disseminate his research through publications in scientific journals, he also directly engages practitioners by organising executive training and seminar events. These events have been attended by senior managers and policy makers from organisations such as MRC Technology, Reneuron, Astex Pharmaceuticals, GlaxoSmithKline, Pfizer, TSB, Cell Therapy Catapult, and the UK Departments of Health, and Business, Innovation, and Skills.