Simcha’s research builds on theory in the sociology, technology management, and entrepreneurship literature to advance our understanding of the changing organisational dynamics of knowledge-intensive work. Specifically, Simcha’s projects examine challenges involved in building successful science-based ventures, in implementing disruptive technological innovations in healthcare settings, and in organising scientific work in an academic landscape that is increasingly internationally interconnected and tied into industrial R&D.
Simcha’s work provides templates of business models for science-based ventures and insights into trade-offs managers of such ventures face in the development of R&D strategies. Also, Simcha’s group developed new valuation tools for science-based R&D projects in the context of a £1.2 Million TSB-funded British Regen Industry Tool Set project on the cell therapy sector. Simcha’s research in this field relies on collaborations with and funding support from companies and other stakeholders in science-based industries. Seminars Simcha organised around his research in this area have attracted CEO’s, R&D Directors, and other senior managers from organisations such as MRC Technology, Reneuron, Astex Pharmaceuticals, GlaxoSmithKline, Pfizer, Cell Therapy Catapult, and the UK Departments of Health, and Business, Innovation, and Skills.
Challenges healthcare organisations face in the adoption of organisationally disruptive innovations in the field of personalised medicine constitute another scholarly focus. With support from industry and a £255k TSB Stratified Medicines program grant, Simcha teamed up with Janssen Pharmaceuticals, UCL Partners, UCLH, and the Royal Free Hospital to develop organisational frameworks for the implementation of novel point of care diagnostics services, and valuation methods to assess the various patient stratification strategies such novel diagnostics services make possible.
Finally, Simcha has made important contributions to the study of changing organisational dynamics in science as academic work has become more international, and closely interlinked with industrial R&D. Simcha published articles that examine institutional models governing academic work in the life sciences at Silicon Valley universities Berkeley, Stanford, and UCSF that are central nodes in biomedical innovation networks. Currently, Simcha is working on projects that examine the organisation and politics of international scientific consortia, as well as changes in European systems of higher learning. Simcha has a strong track record in engaging those involved in science and higher education policy as well as senior academics within this research stream.